New Brunswick™ CelliGen® 510

Agency

Eppendorf

New Brunswick™ CelliGen® 510

SIP benchtop reactors designed to meet the needs of R&D through production.

Product Information

The CelliGen 510 is a compact sterilizable-in-place cell culture system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.

Gas flow
  • Various combinations of one, two, three or four TMFCs:
    • 0.06  –   3 SLPM
    • 0.3  –   15 SLPM
    • 0.6  –   32 SLPM
    • 1  –   64 SLPM
  • Air Wash System with TMFC (0  – 15 or 0  –  32 SLPM)
  • Overlay with TMFC (0 –  15 or 0  – 32 SLPM)
  • Overlay (valve only)
Exhaust line
  • Exhaust condenser
  • Manual or automatic pressure control
Impellers
  • Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts, and algae, where maximum OTR is desired.
  • Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial and radial mixing. Provided as standard with the CelliGen 510 bioreactors.
  • Marine – Commonly used with mammalian, insect, or other shear sensitive cell lines for batch, fed-batch or continuous cultures. Produces axial mixing
  • Spinfilter – For suspension or microcarrier cultures where a dip tube inside the filter withdraws cell media as harvest or waste
  • Cell-Lift – Specially designed to provide uniform circulation for both suspension and microcarrier cultures. Can be used with optional decanting columns for perfusion cultures
  • Packed-bed – For secreted products from anchorage-dependent and suspension cells, this impeller immobilizes cells in a bed of Fibra-Cel® Disks to provide extremely high cell densities
Sensors
  • Single or redundant pH/DO
  • Redox
  • Foam/level
Addition and sampling
  • Resterilizable sampling valve
  • Resterilizable addition valves (4 max)
  • Resterilizable addition/harvest valve with dip tube (2 max)
  • 1.5 in sanitary fitting 7-port septum
  • Addition vessels (glass/stainless steel)
  • Decanters
  • Sterile sampling assembly
Validation
  • Basic Package
  • Basic Plus Package
  • Enhanced Package
Utility regulator & pre-filter kits
  • Process air pre-filter/regulator kit
  • Instrument air pre-filter/regulator kit
  • Water pre-filter/regulator kit
  • Process steam regulator kit
  • Utility steam pre-filter/regulator kit
  • Utility connection kit
Additional options
  • Allen Bradley® CompactLogix™ PLC Control System
  • Sprayballs for clean-in-place of vessel
  • External variable-speed pumps› External scales
  • Spare parts kits› Preventative maintenance kits
  • Mobile table
  • System passivation
  • Glycol/chiller heat exchanger

Features

  • RPC (Reactor Process Control) software or optional Allen Bradley PLC
  • 32 L stainless-steel electropolished vessels with 2:1 aspect ratios
  • Integrated load cell
  • 3-Fixed speed peristaltic pumps for the additions, harvest, and pH control
  • Benchtop or Mobile option
  • Choice of pitched-blade, marine, spin filter, cell-lift or packed-bed impellers
  • industrial touchscreen interface

Applications

  • Laboratory- and pilot-scale fermentation of aerobic and anaerobic bacteria, yeasts, and fungi
  • Laboratory- and pilot-scale cell culture of mammalian, insect, and human cell lines
  • Special applications such as stem cell culture, vaccine, monoclonal antibody or biofuel/biopolymer production
  • Suitable for batch, fed-batch, and continuous/perfusion processes
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